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ban orl24  (MedChemExpress)


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    MedChemExpress ban orl24
    LY2940094 promotes oligodendrocytes generation by an NOPR independent pathway . (A-C) Effect of NOPR antagonists JTC-804 (A), SB-612111(B) and BAN <t>ORL24</t> (C) in OPC-to-OL differentiation. NPC-derived OPCs were differentiated in the presence of various concentration of these compounds for 4 days, OLs were stained with antibody against MBP (red) and percentage of MBP + cells were analyzed. (D–F) Effect of NOPR knockdown in OPC-to-OL differentiation. NPC-derived OPCs were infected with indicated lentivirus or lentivirus mixture carrying shRNAs that target Oprl1 , then allow to differentiate in the presence of solvent control, LY2940094 (2.5 ​μM) and As-2P (100 ​μM) for 4 days, and MBP + cells were pictured (D) and analyzed (F), knockdown efficiency was quantified with qPCR analysis (E). (G) NPC-derived OPCs were treated with LY2940094 (2.5 ​μM) for various time, cell lysates were immunoblotted with the indicated antibodies. PD (ERK1/2 inhibitor PD0325901) was used as positive control. (H, I) Quantitative real time PCR analysis of the expression of myelin-related genes (H) and OLs differentiation-associated transcription factors (I) in LY2940094 treated or control cells. Results were normalized to β-actin and then normalized to the control (Ctrl) group. Data are means ​± ​SEM (n ​= ​3), ∗ p ​< ​0.05, ∗∗ p ​< ​0.01, ∗∗∗ p ​< ​0.001, ∗∗∗∗ p ​< ​0.0001 versus Ctrl group.
    Ban Orl24, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 92/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/ban orl24/product/MedChemExpress
    Average 92 stars, based on 2 article reviews
    ban orl24 - by Bioz Stars, 2026-02
    92/100 stars

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    1) Product Images from "LY2940094, an NOPR antagonist, promotes oligodendrocyte generation and myelin recovery in an NOPR independent manner"

    Article Title: LY2940094, an NOPR antagonist, promotes oligodendrocyte generation and myelin recovery in an NOPR independent manner

    Journal: Neurotherapeutics

    doi: 10.1016/j.neurot.2024.e00424

    LY2940094 promotes oligodendrocytes generation by an NOPR independent pathway . (A-C) Effect of NOPR antagonists JTC-804 (A), SB-612111(B) and BAN ORL24 (C) in OPC-to-OL differentiation. NPC-derived OPCs were differentiated in the presence of various concentration of these compounds for 4 days, OLs were stained with antibody against MBP (red) and percentage of MBP + cells were analyzed. (D–F) Effect of NOPR knockdown in OPC-to-OL differentiation. NPC-derived OPCs were infected with indicated lentivirus or lentivirus mixture carrying shRNAs that target Oprl1 , then allow to differentiate in the presence of solvent control, LY2940094 (2.5 ​μM) and As-2P (100 ​μM) for 4 days, and MBP + cells were pictured (D) and analyzed (F), knockdown efficiency was quantified with qPCR analysis (E). (G) NPC-derived OPCs were treated with LY2940094 (2.5 ​μM) for various time, cell lysates were immunoblotted with the indicated antibodies. PD (ERK1/2 inhibitor PD0325901) was used as positive control. (H, I) Quantitative real time PCR analysis of the expression of myelin-related genes (H) and OLs differentiation-associated transcription factors (I) in LY2940094 treated or control cells. Results were normalized to β-actin and then normalized to the control (Ctrl) group. Data are means ​± ​SEM (n ​= ​3), ∗ p ​< ​0.05, ∗∗ p ​< ​0.01, ∗∗∗ p ​< ​0.001, ∗∗∗∗ p ​< ​0.0001 versus Ctrl group.
    Figure Legend Snippet: LY2940094 promotes oligodendrocytes generation by an NOPR independent pathway . (A-C) Effect of NOPR antagonists JTC-804 (A), SB-612111(B) and BAN ORL24 (C) in OPC-to-OL differentiation. NPC-derived OPCs were differentiated in the presence of various concentration of these compounds for 4 days, OLs were stained with antibody against MBP (red) and percentage of MBP + cells were analyzed. (D–F) Effect of NOPR knockdown in OPC-to-OL differentiation. NPC-derived OPCs were infected with indicated lentivirus or lentivirus mixture carrying shRNAs that target Oprl1 , then allow to differentiate in the presence of solvent control, LY2940094 (2.5 ​μM) and As-2P (100 ​μM) for 4 days, and MBP + cells were pictured (D) and analyzed (F), knockdown efficiency was quantified with qPCR analysis (E). (G) NPC-derived OPCs were treated with LY2940094 (2.5 ​μM) for various time, cell lysates were immunoblotted with the indicated antibodies. PD (ERK1/2 inhibitor PD0325901) was used as positive control. (H, I) Quantitative real time PCR analysis of the expression of myelin-related genes (H) and OLs differentiation-associated transcription factors (I) in LY2940094 treated or control cells. Results were normalized to β-actin and then normalized to the control (Ctrl) group. Data are means ​± ​SEM (n ​= ​3), ∗ p ​< ​0.05, ∗∗ p ​< ​0.01, ∗∗∗ p ​< ​0.001, ∗∗∗∗ p ​< ​0.0001 versus Ctrl group.

    Techniques Used: Derivative Assay, Concentration Assay, Staining, Knockdown, Infection, Solvent, Control, Positive Control, Real-time Polymerase Chain Reaction, Expressing



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    ban orl24  (MedChemExpress)
    92
    MedChemExpress ban orl24
    LY2940094 promotes oligodendrocytes generation by an NOPR independent pathway . (A-C) Effect of NOPR antagonists JTC-804 (A), SB-612111(B) and BAN <t>ORL24</t> (C) in OPC-to-OL differentiation. NPC-derived OPCs were differentiated in the presence of various concentration of these compounds for 4 days, OLs were stained with antibody against MBP (red) and percentage of MBP + cells were analyzed. (D–F) Effect of NOPR knockdown in OPC-to-OL differentiation. NPC-derived OPCs were infected with indicated lentivirus or lentivirus mixture carrying shRNAs that target Oprl1 , then allow to differentiate in the presence of solvent control, LY2940094 (2.5 ​μM) and As-2P (100 ​μM) for 4 days, and MBP + cells were pictured (D) and analyzed (F), knockdown efficiency was quantified with qPCR analysis (E). (G) NPC-derived OPCs were treated with LY2940094 (2.5 ​μM) for various time, cell lysates were immunoblotted with the indicated antibodies. PD (ERK1/2 inhibitor PD0325901) was used as positive control. (H, I) Quantitative real time PCR analysis of the expression of myelin-related genes (H) and OLs differentiation-associated transcription factors (I) in LY2940094 treated or control cells. Results were normalized to β-actin and then normalized to the control (Ctrl) group. Data are means ​± ​SEM (n ​= ​3), ∗ p ​< ​0.05, ∗∗ p ​< ​0.01, ∗∗∗ p ​< ​0.001, ∗∗∗∗ p ​< ​0.0001 versus Ctrl group.
    Ban Orl24, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/ban orl24/product/MedChemExpress
    Average 92 stars, based on 1 article reviews
    ban orl24 - by Bioz Stars, 2026-02
    92/100 stars
    		  Buy from Supplier

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    LY2940094 promotes oligodendrocytes generation by an NOPR independent pathway . (A-C) Effect of NOPR antagonists JTC-804 (A), SB-612111(B) and BAN ORL24 (C) in OPC-to-OL differentiation. NPC-derived OPCs were differentiated in the presence of various concentration of these compounds for 4 days, OLs were stained with antibody against MBP (red) and percentage of MBP + cells were analyzed. (D–F) Effect of NOPR knockdown in OPC-to-OL differentiation. NPC-derived OPCs were infected with indicated lentivirus or lentivirus mixture carrying shRNAs that target Oprl1 , then allow to differentiate in the presence of solvent control, LY2940094 (2.5 ​μM) and As-2P (100 ​μM) for 4 days, and MBP + cells were pictured (D) and analyzed (F), knockdown efficiency was quantified with qPCR analysis (E). (G) NPC-derived OPCs were treated with LY2940094 (2.5 ​μM) for various time, cell lysates were immunoblotted with the indicated antibodies. PD (ERK1/2 inhibitor PD0325901) was used as positive control. (H, I) Quantitative real time PCR analysis of the expression of myelin-related genes (H) and OLs differentiation-associated transcription factors (I) in LY2940094 treated or control cells. Results were normalized to β-actin and then normalized to the control (Ctrl) group. Data are means ​± ​SEM (n ​= ​3), ∗ p ​< ​0.05, ∗∗ p ​< ​0.01, ∗∗∗ p ​< ​0.001, ∗∗∗∗ p ​< ​0.0001 versus Ctrl group.

    Journal: Neurotherapeutics

    Article Title: LY2940094, an NOPR antagonist, promotes oligodendrocyte generation and myelin recovery in an NOPR independent manner

    doi: 10.1016/j.neurot.2024.e00424

    Figure Lengend Snippet: LY2940094 promotes oligodendrocytes generation by an NOPR independent pathway . (A-C) Effect of NOPR antagonists JTC-804 (A), SB-612111(B) and BAN ORL24 (C) in OPC-to-OL differentiation. NPC-derived OPCs were differentiated in the presence of various concentration of these compounds for 4 days, OLs were stained with antibody against MBP (red) and percentage of MBP + cells were analyzed. (D–F) Effect of NOPR knockdown in OPC-to-OL differentiation. NPC-derived OPCs were infected with indicated lentivirus or lentivirus mixture carrying shRNAs that target Oprl1 , then allow to differentiate in the presence of solvent control, LY2940094 (2.5 ​μM) and As-2P (100 ​μM) for 4 days, and MBP + cells were pictured (D) and analyzed (F), knockdown efficiency was quantified with qPCR analysis (E). (G) NPC-derived OPCs were treated with LY2940094 (2.5 ​μM) for various time, cell lysates were immunoblotted with the indicated antibodies. PD (ERK1/2 inhibitor PD0325901) was used as positive control. (H, I) Quantitative real time PCR analysis of the expression of myelin-related genes (H) and OLs differentiation-associated transcription factors (I) in LY2940094 treated or control cells. Results were normalized to β-actin and then normalized to the control (Ctrl) group. Data are means ​± ​SEM (n ​= ​3), ∗ p ​< ​0.05, ∗∗ p ​< ​0.01, ∗∗∗ p ​< ​0.001, ∗∗∗∗ p ​< ​0.0001 versus Ctrl group.

    Article Snippet: LY2940094, JTC-801, SB-612111, BAN ORL24, and nociceptin were purchased from MedChemExpress.

    Techniques: Derivative Assay, Concentration Assay, Staining, Knockdown, Infection, Solvent, Control, Positive Control, Real-time Polymerase Chain Reaction, Expressing